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Antiapoptotic role of major royal jelly protein 8 of honeybee (Apis mellifera) venom
Affiliation:College of Natural Resources and Life Science, Dong-A University, Busan 49315, Republic of Korea
Abstract:The dominant protein components of honeybee royal jelly (RJ) are major royal jelly proteins (MRJPs), which exhibit various biological properties. However, the biological basis of why bee venom contains MRJPs and what role MRJPs play in bee venom remains to be elucidated. This study reports the antiapoptotic role of MRJP 8 of Apis mellifera venom (AmMRJP 8) in melittin-treated mammalian cells. Recombinant AmMRJP 8 reduced caspase-3 activity and melittin-induced cell apoptosis. Additionally, recombinant AmMRJP 8 decreased the production levels of H2O2 and proinflammatory molecules. These results indicate that MRJP in bee venom plays a role in cell protection in bee venom-induced inflammatory responses.
Keywords:Honeybee  Royal jelly  Major royal jelly protein  Venom
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