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Lysine acetylation restricts mutant IDH2 activity to optimize transformation in AML cells
Affiliation:1. Department of Hematology and Medical Oncology, Emory University School of Medicine, Atlanta, GA 30322, USA;2. Department of Radiology and Imaging Sciences, Emory University School of Medicine, Atlanta, GA 30322, USA;3. Winship Cancer Institute, Emory University School of Medicine, Atlanta, GA 30322, USA;4. Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA;5. Section of Hematology and Oncology, Department of Medicine, The University of Chicago, Chicago, IL 60637, USA;6. Department of Chemistry, The University of Chicago, Chicago, IL 60637, USA;7. The Ben May Department for Cancer Research, The University of Chicago, Chicago, IL 60637, USA;8. Department of Systems Biology, Beckman Research Institute of City of Hope, Duarte, CA 91010, USA;9. Department of Pharmacology, Yale University School of Medicine, New Haven, CT 06520, USA
Abstract:
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  • Keywords:mutant IDH2  2-HG  AML  K413 acetylation  FLT3  ACAT1  SIRT3  dimerization
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