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Structure of the human signal peptidase complex reveals the determinants for signal peptide cleavage
Affiliation:1. Structural Biochemistry, Bijvoet Centre for Biomolecular Research, Utrecht University, Universiteitsweg 99, 3584 CG, Utrecht, the Netherlands;2. Biomolecular Mass Spectrometry and Proteomics, Bijvoet Centre for Biomolecular Research and Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Padualaan 8, 3584 CH, Utrecht, the Netherlands;3. Netherlands Proteomics Centre, Padualaan 8, 3584 CH, Utrecht, the Netherlands;4. Groningen Biomolecular Sciences and Biotechnology Institute and Zernike Institute for Advanced Material, University of Groningen, Nijenborgh 7, 9747 AG, Groningen, the Netherlands;5. Molecular Microbiology and Structural Biochemistry, UMR 5086, CNRS and University of Lyon, Lyon, France;6. Institute of Chemistry and Metabolomics, University of Lübeck, Ratzeburger Allee 160, 23562 Lübeck, Germany
Abstract:
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  • Keywords:signal peptidase complex  signal peptide  protein maturation  protein secretion  ER translocon  membrane thinning  cryo-EM  crosslinking mass spectrometry  molecular dynamics simulations  secretory pathway
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