Phylogenetic diversity of stress signalling pathways in fungi |
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| Authors: | Elissavet Nikolaou Ino Agrafioti Michael Stumpf Janet Quinn Ian Stansfield Alistair JP Brown |
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| Affiliation: | (1) Aberdeen Fungal Group, School of Medical Sciences, University of Aberdeen, Institute of Medical Sciences, Foresterhill, Aberdeen, AB25 2ZD, UK;(2) Centre for Bioinformatics, Division of Molecular Biosciences, Wolfson Building, Imperial College London, South Kensington Campus, London, SW7 2AZ, UK;(3) Institute for Cell and Molecular Biosciences, Faculty of Medical Sciences, Newcastle University, 3rd Floor, Catherine Cookson Building, Framlington Place, Newcastle upon Tyne, NE2 4HH, UK |
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| Abstract: | Background Microbes must sense environmental stresses, transduce these signals and mount protective responses to survive in hostile environments. In this study we have tested the hypothesis that fungal stress signalling pathways have evolved rapidly in a niche-specific fashion that is independent of phylogeny. To test this hypothesis we have compared the conservation of stress signalling molecules in diverse fungal species with their stress resistance. These fungi, which include ascomycetes, basidiomycetes and microsporidia, occupy highly divergent niches from saline environments to plant or mammalian hosts. |
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