Factors controlling the rhythmic contraction of collagen gels by neonatal heart cells |
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| Authors: | Jan E M Souren Chris Schneijdenberg Arie J Verkleij Roeland van Wijk |
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| Institution: | (1) Department of Molecular Cell Biology, University of Utrecht, Padualaan 8, 3584 CH Utrecht, The Netherlands |
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| Abstract: | Summary A floating collagen matrix culture of neonatal rat heart myocardial cells shows rhythmic contractions which are dependent
on localization of cells, cell density, and collagen concentration. The rhythmic contractions of the collagen matrix can be
registered by a device scanning the optical density at the edge of the gel and have been observed over a temperature range
from 9° to 40° C. The results of the present study underline the usefulness of myocardial cell populated collagen matrixes
for studies on coherent contractions of heart cell cultures. |
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| Keywords: | collagen neonatal heart cells rat temperature cell density |
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