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Paucimannose N-glycans in Caenorhabditis elegans and Drosophila melanogaster
Authors:Harry Schachter  
Affiliation:aMolecular Structure and Function Program, Hospital for Sick Children, University of Toronto, 555 University Avenue, Toronto Ont, Canada M5G 1X8
Abstract:
There is a rich diversity of paucimannose N-glycans in worms and flies, and these may play a role in the survival of these organisms. Although paucimannose N-glycans are not expressed in vertebrates, complex N-glycans may take over some of the functions of paucimannose N-glycans. Identification of the target proteins of β-1,2-N-acetylglucosaminyltransferase I (GnTI) in worms and flies and elucidation of their functions may thus lead to a better understanding of the role of GnTI-dependent glycoproteins in the survival/longevity of both invertebrates and vertebrates.
Keywords:N-Glycan   Paucimannose   Caenorhabditis elegans   Drosophila melanogaster   Biosynthesis   Longevity
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