Comparative analysis of anti-hepatitis C virus activity and gene expression mediated by alpha,beta, and gamma interferons |
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| Authors: | Cheney I Wayne Lai Vicky C H Zhong Weidong Brodhag Tessa Dempsey Shannon Lim Charmaine Hong Zhi Lau Johnson Y N Tam Robert C |
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| Institution: | Ribapharm, Inc., Costa Mesa, California 92626, USA. |
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| Abstract: | A direct comparison of the inhibitory effects of alpha, beta, and gamma interferons (IFNs) on replication of a hepatitis C virus subgenomic replicon in a hepatoma cell line revealed similarities in antiviral potency. However, alternate IFN-induced antiviral mechanisms were suggested following observations of striking differences between IFN-gamma and IFN-alpha/beta with respect to strength and durability of the antiviral response and the magnitude and pattern of IFN-mediated gene expression. |
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