| p53、survivin在食管癌中的作用 |
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| 引用本文： | 赵文鹏,路平,苗战会,徐芬. p53、survivin在食管癌中的作用[J]. 现代生物医学进展, 2010, 10(6) |
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| 作者姓名： | 赵文鹏 路平 苗战会 徐芬 |
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| 作者单位： | 新乡医学院第一附属医院,河南,卫辉,453100 |
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| 基金项目： | 吴阶平基金资助项目(WKJ2005-3-006) |
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| 摘 要： | 目的:检测p53和survivin蛋白在食管癌组织中的表达,探讨其意义。方法:应用免疫组织化学法检测食管癌及正常食管粘膜组织中p53、survivin蛋白的表达情况。结果:p53、survivin在食管癌组织中的表达量均高于正常食管粘膜组织(P<0.05),p53、survivin高表达与食管癌淋巴结转移状况差异有关(P<0.05),与性别、年龄、肿瘤长度、浸润深度、分化程度无关(P>0.05)。p53和survivin蛋白在食管癌中表达呈明显正相关性(R=0.218,P<0.05)。结论:p53、survivin在食管癌中高表达(82.1%&71.9%),二者在食管癌的淋巴结转移中发挥重要作用,并具有协同作用。
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| 关 键 词： | 食管肿瘤 survivin p53 免疫组织化学 |
Effect of survivin and C-myc protein expression in esophageal carcinoma |
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| ZHAO Wen-peng,LU Ping,MIAO Zhan-hui,XU Fen. Effect of survivin and C-myc protein expression in esophageal carcinoma[J]. Progress in Modern Biomedicine, 2010, 10(6) |
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| Authors: | ZHAO Wen-peng LU Ping MIAO Zhan-hui XU Fen |
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| Affiliation: | ZHAO Wen-peng,LU Ping,MIAO Zhan-hui,XU Fen (The First Affiliated Hospital,Xinxiang Medical University,Weihui,China 453100) |
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| Abstract: | Objective: To detect the expression of survivin ,p53 protein in esophageal carcinoma,and to elucidate the relationship of their protein expression and their clinicalsignificance.Methods: We detected survivin,p53 protein expression in esophageal carcinoma and normal mucous membrane of esophagus by immunohistochemistry method.Results: The expression rates of survivin,p53 protein were significant different in esophageal carcinoma,and normal mucous membrane of esophagus.In addition,the expression rate of surviv... |
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| Keywords: | esophageal carcinoma survivin p53 immunohistochemistry |
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