Temporal and spatial expression of CCN3 during retina development |
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| Authors: | Maryvonne Laurent Gwenvaël Le Dréau Xavier Guillonneau Cécile Lelièvre Elise Amélie Slembrouck Olivier Goureau Cécile Martinerie Maria Marx |
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| Institution: | 1. INSERM UMR S938 Centre de Recherche de Saint‐Antoine, H?pital Saint Antoine Paris F 75012, France;2. Université Pierre et Marie Curie Paris 6, UMRS_938, Centre de Recherche de Saint‐Antoine, Paris F75005, France;3. Instituto de Biología Molecular de Barcelona, CSIC, Parc Cientific de Barcelona, C/Baldiri i Reixac 21, Barcelona 08028, Spain;4. INSERM, UMR_ S 872, Centre de Recherche des Cordeliers, Paris, France;5. Institut de la Vision, INSERM, UPMC Univ Paris 06, UMR‐S 968, CNRS 7210, Paris, France;6. CNRS UMR3347/INSERM U1021, Centre Universitaire, Orsay, France |
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| Abstract: | NOV/CCN3 is one of the founding members of the CCN (Cyr61 CTGF NOV) family. In the avian retina, CCN3 expression is mostly located within the central region of the inner nuclear layer. As retinal development progresses and this retinal layer differentiates and matures, CCN3 expression forms a dorsal–ventral and a central–peripheral gradient. CCN3 is produced by two glial cell types, peripapillary cells and Müller cells, as well as by horizontal, amacrine, and bipolar interneurons. In retinal neurons and Müller cell cultures, CCN3 expression is induced by activated BMP signaling, whereas Notch signaling decreases CCN3 mRNA and protein levels in Müller cells and has no effect in retinal neurons. In Müller cells, the CCN3 expression detected may thus result from a balance between the Notch and BMP signaling pathways. © 2011 Wiley Periodicals, Inc. Develop Neurobiol, 2012 |
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| Keywords: | NOV/CCN3 Müller cells retina development |
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