Correlations between glycolysis with clinical traits and immune function in bladder urothelial carcinoma |
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Authors: | Kai Che Wenkai Han Danxia Li Shuxia Cui Mingxin Zhang Xiaokun Yang Haitao Niu |
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Institution: | 1.Department of Urology, The Affiliated Hospital of Qingdao University, Qingdao, China;2.Department of Clinical Medicine, Qingdao University, Qingdao, China |
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Abstract: | Background: Glycolysis was a representative hallmark in the tumor microenvironment (TME), and we aimed to explore the correlations between glycolysis with immune activity and clinical traits in bladder urothelial carcinoma (BLCA).Methods: Our study obtained glycolysis scores for each BLCA samples from TCGA by a single-sample gene set enrichment analysis (ssGSEA) algorithm, based on a glycolytic gene set. The relationship between glycolysis with prognosis, clinical characteristics, and immune function were investigated subsequently.Results: We found that enhanced glycolysis was associated with poor prognosis and metastasis in BLCA. Moreover, glycolysis had a close correlation with immune function, and enhanced glycolysis increased immune activities. In other words, glycolysis had a positive correlation with immune activities. Immune checkpoints such as IDO1, CD274, were up-regulated in high-glycolysis group as well.Conclusion: We speculated that in BLCA, elevated glycolysis enhanced immune function, which caused tumor cells to overexpress immune checkpoints to evade immune surveillance. Inhibition of glycolysis might be a promising assistant for immunotherapy in bladder cancer. |
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Keywords: | bladder urothelial carcinoma clinical characteristics glycolysis immune activity |
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