Isolation and characterization of a Listeria monocytogenes mutant strain hyperproducing virulence factors |
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| Authors: | Svetlana Ermolaeva Nina Varfolomeeva Yuri Belyi Igor Tartakovskii |
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| Affiliation: | Lehrstuhl für Mikrobiologie, Theodor-Boveri-Institut für Biowissenschaften, Universität Würzburg, Am Hubland, 97074 Würzburg, Germany;Institut für Medizinische Strahlenkunde und Zellforschung, Würzburg, Germany |
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| Abstract: | ![]()
A mutant strain characterized by hyperproduction of a number of cell wall and supernatant proteins was isolated after N-methyl-N′-nitro-N-nitrosoguanidine treatment of Listeria monocytogenes strain NCTC10527. Several of these proteins were identified as virulence factors. When a wild-type strain was grown in the presence of activated charcoal it was shown to exhibit the same protein pattern as the isolated mutant. |
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| Keywords: | Listeria monocytogenes MAP kinase Raf MEK MAP kinase phosphatase HeLa cell |
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