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Synthesis and cytotoxicity of 2alpha-amido docetaxel analogues
Authors:Fang Wei-Shuo  Liu Ying  Liu Hong-Yan  Xu Shao-Feng  Wang Liang  Fang Qi-Cheng
Affiliation:Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, 1 Xian Nong Tan Street, Beijing 100050, PR China. wfang@imm.ac.cn
Abstract:
Various 2-amido docetaxel analogues were prepared and evaluated for their cytotoxicities. Among them, m-methoxy and m-chlorobenzoylamido analogues were most active but not superior to docetaxel and paclitaxel, and D-seco analogues inactive. Change of 2-benzoate to 2-benzamide may not improve their activities to drug-resistant cell lines.
Keywords:
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