Synthesis and cytotoxicity of 2alpha-amido docetaxel analogues |
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Authors: | Fang Wei-Shuo Liu Ying Liu Hong-Yan Xu Shao-Feng Wang Liang Fang Qi-Cheng |
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Affiliation: | Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, 1 Xian Nong Tan Street, Beijing 100050, PR China. wfang@imm.ac.cn |
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Abstract: | ![]() Various 2-amido docetaxel analogues were prepared and evaluated for their cytotoxicities. Among them, m-methoxy and m-chlorobenzoylamido analogues were most active but not superior to docetaxel and paclitaxel, and D-seco analogues inactive. Change of 2-benzoate to 2-benzamide may not improve their activities to drug-resistant cell lines. |
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