Synthesis and cytotoxicity of 2alpha-amido docetaxel analogues |
| |
| Authors: | Fang Wei-Shuo Liu Ying Liu Hong-Yan Xu Shao-Feng Wang Liang Fang Qi-Cheng |
| |
| Affiliation: | Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, 1 Xian Nong Tan Street, Beijing 100050, PR China. wfang@imm.ac.cn |
| |
| Abstract: | ![]()
Various 2-amido docetaxel analogues were prepared and evaluated for their cytotoxicities. Among them, m-methoxy and m-chlorobenzoylamido analogues were most active but not superior to docetaxel and paclitaxel, and D-seco analogues inactive. Change of 2-benzoate to 2-benzamide may not improve their activities to drug-resistant cell lines. |
| |
| Keywords: | |
| 本文献已被 PubMed 等数据库收录！ |
|
