Native transfer RNA catalyzes Diels-Alder reaction |
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Authors: | Mielcarek Michal Barciszewska Miroslawa Z Sałanski Piotr Stobiecki Maciej Jurczak Janusz Barciszewski Jan |
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Institution: | Institute of Bioorganic Chemistry, Polish Academy of Sciences, Noskowskiego 12, 61704 Poznan, Poland. |
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Abstract: | In this paper we show that transfer ribonucleic acids (tRNAs) catalyze the Diels-Alder cycloaddition reaction. A new DNA oxidative damage product, 6-furfuryladenine (kinetin) or its riboside (diene), was transformed with dimethyl acetylenedicarboxylate or maleic anhydride (dienophile). The reaction proceeds in the presence of tRNA at high pressure but not at ambient condition. If so tRNA in prebiotic conditions (RNA world) had at least two functions: catalytic and a carrier of genetic information. It means that tRNA at high pressure shows catalytic properties and is a true Diels-Alderase. |
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Keywords: | RNA world Diels-Alder reaction RNA catalysis Transfer RNA High pressure Kinetin |
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