Molecular basis for different rates of recovery from inactivation in the Shaker potassium channel family |
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| Authors: | R Wittka M Stocker G Boheim O Pongs |
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| Affiliation: | Ruhr-Universit?t Bochum, Lehrstuhl für Biochemie, Germany. |
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| Abstract: | The two alternative carboxyl-termini of Shaker K+ channels strongly influence the rates of inactivation and of recovery from channel inactivation. We show that this distinct inactivation behaviour is due to an alanine/valine amino acid replacement within the Shaker carboxyl-terminus at a site that occurs within the proposed membrane spanning segment S6. |
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