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Synaptic plasticity of feeding circuits: hormones and hysteresis |
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| Authors: | Dietrich Marcelo O Horvath Tamas L |
| Affiliation: | 1 Section of Comparative Medicine, Yale University School of Medicine, New Haven, CT 06520, USA 2 Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, CT 06520, USA 3 Department of Neurobiology, Yale University School of Medicine, New Haven, CT 06520, USA 4 Programa de Pós-graduação em Bioquímica, Department of Biochemistry, Universidade Federal do Rio Grande do Sul, Porto Alegre RS 90035, Brazil |
| Abstract: | The drive to eat is controlled by neuronal circuits in the hypothalamus that respond to hormones signaling hunger or satiety. In this issue of Cell, Yang et al. (2011) reveal an AMPK-dependent synaptic pathway that sustains excitatory stimulation of the NPY/AgRP neurons that promote feeding behavior until satiety signals kick in. |
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