PINK1 and Parkin flag Miro to direct mitochondrial traffic |
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| Authors: | Kane Lesley A Youle Richard J |
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| Affiliation: | 1 National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA |
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| Abstract: | ![]()
The Parkinson's disease proteins PINK1 and Parkin are proposed guardians of mitochondrial fidelity, targeting damaged mitochondria for degradation by mitophagy. In this issue of Cell, Wang et al. (2011) now show that PINK1 and Parkin also regulate mitochondrial trafficking and quarantine damaged mitochondria by severing their connection to the microtubule network. |
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