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LXRβ deficient mice have reduced hepatic insulin clearance during hyperinsulinemic euglucemic clamp |
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| Authors: | Sverre Holm Hilde I Nebb |
| Institution: | a Institute of Basic Medical Sciences, Department of Nutrition, University of Oslo, P.O. Box 1046 Blindern, N-0316 Oslo, Norway b Department of Endocrinology and Metabolic Diseases, Leiden University Medical Center, C4R, P.O. Box 9600, NL-2300RC Leiden, The Netherlands c Department of Biosciences and Nutrition, NOVUM, S-14157 Huddinge, Sweden d Center for Nuclear Receptors and Cell Signaling, Department of Biology and Biochemistry, University of Houston, 3013 Science & Engineering Research Center, Houston, TX 77204-5056, USA |
| Abstract: | The present study addresses the insulin sensitivity in mice deficient in LXRβ (LXRβ−/−) as well as in wild type (wt) mice assessed by hyperinsulinemic euglycemic clamp. Wt and LXRβ−/− mice were fed either a normal chow diet or a high fat and high cholesterol diet (HFCD), and insulin sensitivity was assessed by hyperinsulinemic euglycemic clamps. We show that LXRβ−/− mice have reduced insulin clearance during hyperinsulinemic clamps upon feeding both HFCD and a regular chow diet. Moreover we also observed reduced hepatic inflammation in LXRβ−/− mice compared to wt mice upon feeding an HFCD, despite equal levels of hepatic steatosis. In summary, our results indicate that LXRβ−/− mice have reduced insulin clearance during hyperinsulinemic euglycemic clamps and also reduced hepatic inflammation upon feeding an HFCD for 26 weeks. |
| Keywords: | Glucose Insulin Hepatic steatosis LXR Insulin clearance |
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