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A potential role for Helicobacter pylori heat shock protein 60 in gastric tumorigenesis |
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| Authors: | Chen-Si Lin Pei-Juin He Chi-Han Li Wei-Tung Hsu Chang-Jer Wu Kuang-Wen Liao |
| Institution: | a Department of Biological Science and Technology, National Chiao-Tung University, Hsin-Chu, Taiwan b School of Veterinary Medicine, National Taiwan University, Taipei, Taiwan c School of Medical Laboratory and Biotechnology, Chung Shan Medical University, Taichung, Taiwan d Department of Internal Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan e Department of Food Science, National Taiwan Ocean University, Keelung, Taiwan f Department of Biotechnology, Kaohsiung Medical University, Kaohsiung, Taiwan |
| Abstract: | Helicobacter pylori has been found to promote the malignant process leading to gastric cancer. Heat shock protein 60 of H. pylori (HpHSP60) was previously been identified as a potent immunogene. This study investigates the role of HpHSP60 in gastric cancer carcinogenesis. The effect of HpHSP60 on cell proliferation, anti-death activity, angiogenesis and cell migration were explored. The results showed that HpHSP60 enhanced migration by gastric cancer cells and promoted tube formation by umbilical vein endothelial cells (HUVECs); however, HpHSP60 did not increase cell proliferation nor was this protein able to rescue gastric cancer cells from death. Moreover, the results also indicated HpHSP60 had different effects on AGS gastric cancer cells or THP-1 monocytic cells in terms of their expression of pro-inflammatory cytokines, which are known to be important to cancer development. We propose that HpHSP60 may trigger the initiation of carcinogenesis by inducing pro-inflammatory cytokine release and by promoting angiogenesis and metastasis. Thus, this extracellular pathogen-derived HSP60 is potentially a vigorous virulence factor that can act as a carcinogen during gastric tumorigenesis. |
| Keywords: | Helicobacter pylori Heat shock protein 60 Tumorigenesis |
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