Stearic acid attenuates cholestasis-induced liver injury |
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Authors: | Pin-Ho Pan Shih-Yi Lin Yen-Chuan Ou Yu-Han Chuang Su-Lan Liao Chun-Jung Chen |
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Institution: | a Department of Pediatrics, Tung’s Taichung MetroHarbor Hospital, Taichung, Taiwan b Division of Endocrinology and Metabolism, Taichung Veterans General Hospital, Taichung, Taiwan c Division of Urology, Taichung Veterans General Hospital, Taichung, Taiwan d Department of Education and Research, Taichung Veterans General Hospital, Taichung, Taiwan e Center for General Education, Tunghai University, Taichung, Taiwan f Institute of Medical and Molecular Toxicology, Chung-Shan Medical University, Taichung, Taiwan g Institute of Biomedical Sciences, National Chung-Hsing University, Taichung, Taiwan |
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Abstract: | Inflammation is involved in cholestasis-induced hepatic damage. Stearic acid has been shown to possess anti-inflammatory potential. We assessed whether stearic acid has protective effects against cholestasis-related liver damage. Cholestasis was produced by bile duct ligation (BDL) in male Sprague-Dawley rats for 3 weeks. Daily administration of stearic acid was started 2 weeks before injury and lasted for 5 weeks. In comparison with the control group, the BDL group showed hepatic damage as evidenced by elevation in serum biochemicals, ductular reaction, fibrosis, and inflammation. These pathophysiological changes were attenuated by chronic stearic acid supplementation. The anti-fibrotic effect of stearic acid was accompanied by reductions in α-smooth muscle actin-positive matrix-producing cells and critical fibrogenic cytokine transforming growth factor beta-1 production. Stearic acid also attenuated BDL-induced leukocyte accumulation and NF-κB activation. The data indicate that stearic acid attenuates BDL-induced cholestatic liver injury. The hepatoprotective effect of stearic acid is associated with anti-inflammatory potential. |
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Keywords: | Cholestasis Hepatotoxicity Inflammation Oxidative stress Stearic acid |
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