Genome-scale metabolic analysis of Clostridium thermocellum for bioethanol production |
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| Authors: | Seth B Roberts Christopher M Gowen J Paul Brooks Stephen S Fong |
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| Affiliation: | (1) Department of Chemical and Life Science Engineering, Virginia Commonwealth University, 23284 Richmond, VA, USA;(2) Department of Statistical Sciences and Operations Research, Virginia Commonwealth University, 23284 Richmond, VA, USA;(3) Center for the Study of Biological Complexity, Virginia Commonwealth University, 23284 Richmond, VA, USA |
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| Abstract: | Background Microorganisms possess diverse metabolic capabilities that can potentially be leveraged for efficient production of biofuels. Clostridium thermocellum (ATCC 27405) is a thermophilic anaerobe that is both cellulolytic and ethanologenic, meaning that it can directly use the plant sugar, cellulose, and biochemically convert it to ethanol. A major challenge in using microorganisms for chemical production is the need to modify the organism to increase production efficiency. The process of properly engineering an organism is typically arduous. |
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