H-2-associated differences in replicated strains of mice divergently selected for body weight |
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| Authors: | Elizabeth Simpson Grahame Bulfield Mary Brenan William Fitzpatrick Colin Hetherington Andrew Blann |
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| Institution: | (1) Transplantation Biology Section, Clinical Research Centre, Watford Road, HA1 3UJ Harrow, Middlesex, UK;(2) Department, of Genetics, University of Leicester, Leicester, UK;(3) Present address: Genetics Group, Agricultural Research Council, Poultry Research Centre, EH25 9PS Roslin, Midlothian, UK;(4) Present address: Department of Pathology, University of Zurich, Zurich, Switzerland;(5) Present address: National Institute of Medical Research, The Ridgeway, Mill Hill, NW7 London, UK;(6) Present address: Celltech Ltd., 250 Bath Road, Slough, Berkshire, UK |
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| Abstract: | A random-bred strain (Q) was established and divided into six replicates. Each replicate was divergently selected for 6-week weight (for over 30 generations) and each had an unselected control. We have investigated the H-2 haplotype of individual mice of the 18 selected Q strains to determine whether selection for size had also selected for H-2 or H-2-linked genes. From the results it appeared that only the H-2
b
and H-2
q
haplotypes were present in the foundation stock. A large number of individuals of the six small sublines were of H-2
bhaplotype, while the majority of those of the six large sublines were of the H-2
q
haplotype. Individuals in the six control strains were H-2
b
, H-2
q
or both (i. e., H-2 heterozygotes and/or H-2 recombinants). These results suggest that control of body size is associated with H-2 or an H-2-linked gene(s). |
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| Keywords: | |
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