| 结核分枝杆菌感染动物模型的研究进展 |
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| 引用本文： | 张昊凌,张志勇.结核分枝杆菌感染动物模型的研究进展[J].微生物与感染,2012,7(3):184-189. |
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| 作者姓名： | 张昊凌 张志勇 |
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| 作者单位： | 1. 复旦大学附属中山医院,上海,200032
2. 复旦大学附属中山医院,上海,200032;上海市(复旦大学附属)公共卫生临床中心,上海,201508 |
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| 摘 要： | 人类结核病位居单一病原引起死亡的严重传染病之首,结核分枝杆菌是其主要病原.尽管结核分枝杆菌可引起许多种动物感染并患病,但人类是其主要宿主.动物模型作为研究人类疾病的标准化工具,虽然不能完全模拟人类结核病的整个过程,但可成为研究结核病的有用工具,有助于研究其发病机制、治疗过程及宿主对病原的免疫病理学反应.由于不同种类动物...
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| 关 键 词： | 结核分枝杆菌 动物模型 结核病 |
Advances in research on animal models of Mycobacterium tuberculosis infection |
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| ZHANG Hao-Ling
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ZHANG Zhi-Yong.Advances in research on animal models of Mycobacterium tuberculosis infection[J].Journal of Microbes and Infection,2012,7(3):184-189. |
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| Authors: | ZHANG Hao-Ling ZHANG Zhi-Yong |
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| Institution: | ZHANG Hao-Ling ZHANG Zhi-Yong 1. Zhongshan Hospital, Fudan University, Shanghai 200032, China 2. Public Health Clinical Center Affiliated to Fudan University, Shanghai 201508, China |
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| Abstract: | Mycobacterium tuberculosis is one of the major human pathogens for tuberculosis, with one-third of the world population being infected. Although this bacterium can infect and cause diseases in many animals, humans are the natural hosts. For the purpose of studying the pathogenesis of Mycobacterium tuberculosis infection, as well as the immunopathology of host responses against this pathogen, suitable animal models play a pivotal role. In this paper, the research models widely used in Mycobacterium tuberculosis infection are elucidated, and their limitations and advantages arc discussed. |
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| Keywords: | Mycobacterium tuberculosis~ Animal model~ Tuberculosis |
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