Antiproliferative activity of berberine in vitro and in vivo |
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Authors: | Letasiová Silvia Jantová Sona Múcková Marta Theiszová Marica |
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Institution: | Department of Biochemistry and Microbiology, Slovak University of Technology, Radlinského 9, Bratislava, Slovak Republic. silvia.letasiova@stuba.sk |
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Abstract: | Berberine, an isoquinoline plant alkaloid acted cytotoxically in vitro on tumour cell lines B16. Its anticancer activity in vivo was studied with the transplanted B16 line in the range of doses from 1 mg/kg to 10 mg/kg. The significant reduction of tumor volume was observed on day 16 at doses of 5 and 10 mg/kg. The dose of 1 mg/kg stimulated the tumor mass, but other tested concentration, 5 and 10 mg/kg, reduced the tumor weight. |
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