Enzymic glycosphingolipid synthesis on polymer supports. |
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| Authors: | Uri Zehavi Mina Herchman Richard R Schmidt Thomas Bär |
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| Affiliation: | (1) Department of Biochemistry and Human Nutrition, Faculty of Agriculture, The Hebrew University of Jerusalem, P.O. Box 12, 76100 Rehovot, Israel;(2) The Biomembrane Institute and University of Washington, 201 Elliott Avenue W., 98119 Seattle, WA, USA;(3) Present address: Fachbereich Chemie, Universität Oldenburg, Postfach 2503, D-2900 Oldenburg, Germany |
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| Abstract: | Two synthetic approaches leading toN-4-carboxymethyl-2-nitrobenzyloxycarbonyl derivatives of model compounds and of glycosylsphingosines are described. The carboxymethyl group can be converted into a hydrazido derivative and the resulting products react with an active ester polymer yielding light-sensitive polymeric products that may subsequently serve as acceptors in glycosyltransferase reactions.Author for correspondence. Address until September 1990; Graduate Department of Biochemistry, Brandeis University, 415 South Street, Waltham, MA 02254, USA |
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| Keywords: | glycosphingolipids synthesis polymer support |
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