NDRG1的功能及其与癌症的关系

细胞生长、分化和多种应激的情况都可以影响NDRGI（N-myc downstream-rvgulatcd gene 1）蛋白的表达水平。NDRG1在许多细胞的正常生理功能中起着重要作用。NDRG1的缺乏可能导致多种疾病，如．碡D型CMTD（夏-马-图三氏病进行性神经性肌萎缩，Charcot-Marie-Toothdisease）的发生与施万细胞中NDRG1的缺失有关。在多种癌细胞系中。NDRG1的转录和翻译与肿瘤的分化和转移有关。在缺氧环境中。NDRG1的表达水平上调，而且在许多肿瘤细胞中都存在缺氧的现象，这使得NDRG1与缺氧和癌症之间存在着复杂的关系。NDRGI与癌症的关系使得NDRG1可能作为肿瘤演进的标识和癌症诊断的辅助工具。

The function of NDRG1 and its relationship with cancer

The expression ofNDRG1 （N-myc downstream-regulated gene 1 ）protein is affected by cell growth, cell differentiation and a wide variety of stress.NDRG1 plays an important role in the physiologic function of cells. The deficiency of NDRG1 may cause many diseases. The probable cause of Charcot-Marie-Tooth type 4D disease is the deficiency of NDRG1 in Schwann cell. The transcrip- tion and translation of NDRG1 correlate with cell differentiation and metastasis in various cancer cell lines. Because it is strongly up-regulated under hypoxic condition, and this condition is prevalent in solid tumors, its regulation is a little complicated. NDRG1 gene may be a marker of tomor progression and an efficient diagnostic tool in many types of cancers.