妊娠肝内胆汁淤积症发生的分子机制研究进展

妊娠肝内胆汁淤积症（Intrahepatic cholestasis of pregnancy, ICP）是发生在妊娠中晚期，以皮肤瘙瘁、黄疸、血清胆汁酸升高，伴轻度肝功能损害为特征的妊娠并发症，严重影响母儿健康。ICP的发病机制尚未完全阐明，但有研究表明在遗传易感性妇女中，性激素及其代谢产物导致胆汁酸代谢异常与本病的发生密切相关。现就目前国内外有关ICP发病机制的研究进展做一综述，一方面为探寻更深层次的机制提供理论基础，另一方面为临床治疗ICP提供思路和方法。

Intrahepatic Cholestasis of Pregnancy

Intrahepatic cholestasis ofpregnancy（ICP） is a pregnancy-specific liver disorder in the third trimester characterized by pruritus, jaundice, raised serum bile acids and mildly abnormal liver function, which adversely affect fetal outcome. The etiology of ICP is not fully understood. Studies have shown that in genetically susceptible women the ICP may result from estrogens and progesterones as well as their metabolities in the last trimester which lead to the abnormal bile acid metabolism. In this article we will conclude the progression on the molecular mechanism about the ICP, on the one hand to help us offer theoretical basis for deeper understanding the pathomechanism, and on the other hand to provide new ideas and methods for clinical treatment.