肥胖患者载脂蛋白M水平及其与炎症因子的关系研究

目的：观察肥胖患者载脂蛋白M水平并探讨其与炎症因子的关系。方法：58例体重正常者和36例肥胖患者常规测量体重、身高，计算体重指数，抽取空腹静脉血检测血脂、血浆载脂蛋白M（apoM）、白细胞介素-6（IL-6）、C反应蛋白（CRP）、肿瘤坏死因子α（TNF—α）。结果：肥胖患者血浆apoM、高密度脂蛋白胆固醇（HDL-C）降低（P〈0．05），IL-6、TNF—α、CRP水平升高（P〈0．05），肥胖患者血浆αpoM与HDL-C正相关，血浆αpoM与IL-6、TNF—α、CRP水平负相关。结论：肥胖患者血浆apoM显著降低，αpoM水平与CRP、TNF-α、IL-6水平密切相关，apoM可能受到这些炎症因子的调控。

Apolipoprotein M Levels and its Relationship with Inflammatory Factors in Obesity

Objective： To observe the level ofapoM in obesity and explore the relationship between apoM and inflammatory factor. Methods： Obese patients （n=36） and healthy volunteers （n=58）were included, and their weight and height were measured. The Plasma apoM, fasting plasma lipids, Interleukin -6 （IL-6）, C-reactive protein （CRP）, tumor necrosis factor-α （TNF-α） were measured. Results： Obesity had lower plasma apoM, lower HDL-C （P〈0.05）. Conversely, 1L-6, TNF-α , CRP increased markedly in obesity group （P〈0.05）. In obesity, apoM was positively related to HDL-C level and negatively related to IL-6, TNF-α and CRP. Conclusions： Obese patients had lower apoM plasma. ApoM levels was closely related to CRP, TNF-α and IL-6 levels in obese patients, apoM may be regulated by these inflammatory factors.