猴腺病毒研究进展

猴腺病毒（simian adenovirus,SAdV）是猴类呼吸道和消化道的常在病毒之一,可引起肺炎、咽炎、肠胃炎、结膜炎等以粪口途径传播为主,主要感染猕猴、非洲绿猴、黑猩猩和狒狒等1]属腺病毒科,哺乳动物腺病毒属。有学者认为SAdV感染有严格的种属特异性,也有报道认为其种间交叉传播在非人灵长类中可能普遍发生,是动物传染病似的感染。SAdV是否感染人类尚未见报道,但已从猴的分泌物中发现了可能和人腺病毒（humanadenovirus,HAdV）发生重组的新型腺病毒。SAdV与HAdV亲缘关系很近,感染引起的临床症状也相似,是人腺病毒研究的理想模型。目前已经制定了研发猴腺病毒模型的目标,用于研究感染机制,促进腺病毒基因治疗和疫苗开发进程3]。但猴腺病毒自然感染流行情况的研究依然很少。本文将就SAdV的发现与分类、生物学特性、感染特点及检测方法做一综述,为研究者提供一些有用参考。

The Research Progress of Simian Adenovirus

Simian adenovirus（SAdV）,as common viral agent persistent in respiratory and gastrointestinal tract of non-human primates,can cause pneumonia,gastroenteritis and conjunctivitis and spread mainly by Fecal-oral way.SadV can infect macaques,chimpanzees,baboons,etal belonging to genus Mastadenovirus.Some resarchers agured that SadV had strict species specificity.Other reports suggested that cross species transmission may be a common occurance and is zoonotic transmission.No report says SadV can infect human,but found a novel adenovirus serotype that may be recombination with a human adenovirus.SadV and HadV are close,casuing similar clinical symptoms,which make it a good model for adenovirus research.To date,the goal of developing a non-human primate adenovirus model has been made to study the mechanisms of infection and promote progress on gene therapies and genetic vaccines with adenovirus vector.However,little is known about the prevalence of adenovirus infection in non-human primates.This article reviewed discovery and classification,biological characterization,and detection of SAdV so as to provide some useful insights for researchers.