| 青藤碱对慢性非细菌性大鼠前列腺炎大鼠炎症反应及P38Mapk信号通路的影响 |
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| 引用本文： | 李兴森,黄飚,吴文强,蒲世年,张荣贵.青藤碱对慢性非细菌性大鼠前列腺炎大鼠炎症反应及P38Mapk信号通路的影响[J].生物磁学,2011(22):4244-4246. |
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| 作者姓名： | 李兴森 黄飚 吴文强 蒲世年 张荣贵 |
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| 作者单位： | [1]重庆市綦江县人民医院,重庆401420 [2]重庆医科大学附属第二医院泌尿外科,重庆400042 |
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| 摘 要： | 目的：观察青藤碱对慢性非细菌性大鼠前列腺炎大鼠炎症反应及P38Mapk信号通路的影响。方法：将SD大鼠随机分为对照组、青藤碱高、低剂量组。对照组组给予生理盐水灌胃，青藤碱低、中、高剂量组分别给予青藤碱40,80、160mg／kg灌胃，28天后处死。realtimeRT-PCR法和westernblot法检测肿瘤组织中TNF-、IL-6rnR_NA和TNF-、IL-6、P—P38MAPK蛋白的表达。结果：青藤碱能明显降低慢性非细菌性大鼠前列腺炎大鼠前5,1腺组织中TNF-、IL-6mRNA和TNF-、IL-6、p-P38MAPK蛋白的表达。结论：青藤碱能抑制慢性非细菌性大鼠前列腺炎大鼠前列腺炎症反应，其机制可能与抑制P38MAP信号通路有关。
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| 关 键 词： | 青藤碱 前列腺炎 TNF- IL-6 p-P38 MAPK |
The Effect of Sinomenin on Chronic Prostategland Inflammation in Rats |
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| LI Xing-sen,HUANG Biao,WU Wen-qiang,PU Shi-nian,ZHANG Rong-gui.The Effect of Sinomenin on Chronic Prostategland Inflammation in Rats[J].Biomagnetism,2011(22):4244-4246. |
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| Authors: | LI Xing-sen HUANG Biao WU Wen-qiang PU Shi-nian ZHANG Rong-gui |
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| Institution: | 1 The people hospital of qijiang county, Chongqing, 401420; 2 Urinary surgery, The second attliated hospital of Chongqing medical univerci chongqing, 400042) |
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| Abstract: | Objective： To study the effect of sinomenin on chronic prostategland inflammation in rats. Methods： Sprague Dawley rats were divide into normal group, sinomenin 40,80,160mg/kg groups. Contents of TNF-α, IL-6 mRNA and TNF-α, IL-6, p-P38 MAPK protein were detected by il real-time PCR and western blot methods, respectivly. Results： In sinomenin groups, Contents of TNF-α, IL-6 mRNA and TNF-α, IL-6, p-P38 MAPK protein were decreased markedly. Conclusion： Sinomenin could inhibit chronic prostategland in- flammation in rats. This maybe be concerned with that it could inhibit the expression of p-P38 MAPK in prostategland of rats. |
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| Keywords: | Sinomenin Prostategland Inflammation IL-6 p-P38 MAPK |
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