| PTEN和EGFR在胃癌中的表达及相关性研究 |
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| 引用本文： | 张瑞,邹赛英,樊平.PTEN和EGFR在胃癌中的表达及相关性研究[J].现代生物医学进展,2010,10(2). |
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| 作者姓名： | 张瑞 邹赛英 樊平 |
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| 作者单位： | 1. 石河子大学医学院,新疆,石河子,832002
2. 兰州军区乌鲁木齐总医院病理科,新疆,乌鲁木齐,830000 |
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| 摘 要： | 目的:检测第10号染色体缺失的磷酸酶和张力蛋白同源物基因PTEN及表皮生长因子受体EGFR在胃癌组织中的表达,探讨两者与胃癌肿瘤行为的关系及意义。方法:采用免疫组织化学染色法(S-P法)检测105例胃癌组织及癌旁正常胃组织中EGFR和PTEN蛋白的表达水平,并将检测结果与临床病理参数进行综合分析。结果:胃癌组织PTEN的表达56.19%明显低于正常组织中的表达的表达92.3%,而胃癌组织EGFR的表达46.67%明显高于正常组织7.62%,(P<0.01)。二者的表达与性别和年龄无相关性(P>0.05),与胃癌的分化程度、浸润深度、淋巴结转移及临床分期有相关性(P<0.05)。结论:PTEN在胃癌组织中呈低表达,EGFR在胃癌组织中存在高表达,与胃癌的发生、发展有一定关系,并与胃癌的分化程度、浸润深度、淋巴结转移及临床分期密切相关,二者呈负相关。
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| 关 键 词： | PTEN EGFR 胃癌 免疫组织化学 |
Expression and relationship between PTEN and EGFR in gastric carcinoma |
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| ZHANG Rui,ZOU Sai-ying,FAN Pin.Expression and relationship between PTEN and EGFR in gastric carcinoma[J].Progress in Modern Biomedicine,2010,10(2). |
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| Authors: | ZHANG Rui ZOU Sai-ying FAN Pin |
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| Institution: | ZHANG Rui1,ZOU Sai-ying2,FAN Pin1(1 Medical collage of Shihezi University1Shihezi,832002,China,2 Department of Pathology,Urumqi General Hospital Lanzhou Comm,,PLA,Urumqi 830000,China) |
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| Abstract: | Objective:To investigate expression of PTEN and EGFR in gastric carcinoma and to explore its relationship with the genesis and development of gastric carcinoma and its relationship with clinicopathological parameters. Methods:Immunohistochemistry(S-P) was used to detect the expression of PTEN and EGFR protein in 105 case of gastric carcinoma tissues and their adjacent normal gastric tissues. Results:In the normal gastric tissue,the positive rate of PTEN protein(92.3%) were higher than those in gastric cance... |
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| Keywords: | PTEN EGFR |
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