Adaptive evolution of the spike gene of SARS coronavirus: changes in positively selected sites in different epidemic groups |
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| Authors: | Chi-Yu Zhang Ji-Fu Wei and Shao-Heng He |
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| Institution: | (1) Department of Biochemistry and Molecular Biology, Jiangsu University School of Medical Technology, 212001 Zhenjiang, Jiangsu, China;(2) The First Affiliated Hospital of Nanjing Medical University, 210026 Nanjing, Jiangsu, China |
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| Abstract: | Background It is believed that animal-to-human transmission of severe acute respiratory syndrome (SARS) coronavirus (CoV) is the cause
of the SARS outbreak worldwide. The spike (S) protein is one of the best characterized proteins of SARS-CoV, which plays a
key role in SARS-CoV overcoming species barrier and accomplishing interspecies transmission from animals to humans, suggesting
that it may be the major target of selective pressure. However, the process of adaptive evolution of S protein and the exact
positively selected sites associated with this process remain unknown. |
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