首页 | 本学科首页   官方微博 | 高级检索  
     


Structural features and in vivo antitussive activity of the water extracted polymer from Glycyrrhiza glabra
Authors:Saha Sudipta  Nosál'ová Gabriella  Ghosh Debjani  Flešková Dana  Capek Peter  Ray Bimalendu
Affiliation:Natural Products Laboratory, Department of Chemistry, The University of Burdwan, WB 713 104, India.
Abstract:
Antitussive drugs are amongst the most widely used medications worldwide; however no new class of drugs has been introduced into the market for many years. Herein, we have analyzed the water-extracted polymeric fraction (WE) of Glycyrrhiza glabra. This arabinogalactan protein enriched fraction, ≥ 85% of which gets precipitated with Yariv reagent, consisted mainly of 3- and 3,6-linked galactopyranosyl, and 5- and 3,5-linked arabinofuranosyl residues. Peroral administration of this polymer in a dose of 50mg/kg body weight decreases the number of citric acid induced cough efforts in guinea pigs more effectively than codeine. It does not induce significant change in the values of specific airway resistance or provoked any observable adverse effects.
Keywords:
本文献已被 PubMed 等数据库收录!
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号