Loss of HB-EGF in smooth muscle or endothelial cell lineages causes heart malformation |
| |
| Authors: | Nanba Daisuke Kinugasa Yumi Morimoto Chie Koizumi Michiko Yamamura Hisako Takahashi Katsuhito Takakura Nobuyuki Mekada Eisuke Hashimoto Koji Higashiyama Shigeki |
| |
| Affiliation: | Department of Biochemistry and Molecular Genetics, Ehime University Graduate School of Medicine, Shitsukawa, To-on, Ehime 791-0295, Japan. |
| |
| Abstract: | Epidermal growth factor (EGF) and ErbB family molecules play a role in heart development and function. To investigate the role of EGF family member, heparin-binding EGF-like growth factor (HB-EGF) in heart development, smooth muscle and endothelial cell lineage-specific HB-EGF knockout mice were generated using the Cre/loxP system in combination with the SM22alpha or TIE2 promoter. HB-EGF knockout mice displayed enlarged heart valves, and over half of these mice died during the first postnatal week, while survivors showed cardiac hypertrophy. These results suggest that expression of HB-EGF in smooth muscle and/or endothelial cell lineages is essential for proper heart development and function in mice. |
| |
| Keywords: | Cardiac hypertrophy Conditional knockout HB-EGF Heart valves Heart failure |
| 本文献已被 ScienceDirect PubMed 等数据库收录！ |
