Proteinuria in neonatal piglets after oral and intravenous administration of homologous colostrum and serum proteins |
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| Affiliation: | 1. Section of Cardiovascular Medicine, Yale School of Medicine, New Haven, Connecticut, USA;2. 3rd Department of Medicine, Cardiology and Intensive Care Medicine, Wilhelminen Hospital, and Sigmund Freud University, Medical Faculty, Vienna, Austria;3. TIMI Study Group, Cardiovascular Division, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, USA;4. Department of Internal Medicine II, Division of Cardiology Medical University of Vienna, Vienna, Austria;5. Duke Clinical Research Institute, Durham, North Carolina, USA;6. Department of Cardiology, Heart Center Leipzig at University of Leipzig, Leipzig, Germany;7. Northwell Health, Zucker School of Medicine, Hempstead, New York, USA;8. Department of Clinical-Surgical, Diagnostic and Pediatric Sciences, University of Pavia, Intensive Care Fondazione Policlinico San Matteo Hospital IRCCS, Pavia, Italy;9. Critical Care Medicine Department, National Institutes of Health Clinical Center and Cardiovascular Branch, National Heart, Lung, and Blood Institute of the National Institutes of Health, Bethesda, Maryland, USA;10. Department of Cardiology, Aarhus University Hospital, Aarhus N, Denmark;1. Medizinische Klinik und Poliklinik I, Klinikum der Universität München, Munich, Germany;2. German Center for Cardiovascular Research, Partner Site Munich Heart Alliance, Munich, Germany;3. Department of Cardiology, Heart Center Leipzig, University of Leipzig, Leipzig, Germany;4. Department of Cardiology, University Heart and Vascular Center Hamburg, University Medical Center Hamburg-Eppendorf, Hamburg, Germany;5. German Center for Cardiovascular Research, Partner Site/Hamburg/Lübeck/Kiel, Hamburg, Germany;6. Universitätsklinik für Kardiologie, Inselspital Bern, Bern, Switzerland;7. Department of General and Interventional Cardiology, Heart and Diabetes Center North Rhine-Westphalia, Ruhr University Bochum, Bad Oeynhausen, Germany;1. Cardiovascular Center Aalst, OLV-Clinic, Aalst, Belgium;2. Division of University Cardiology, IRCCS Galeazzi – Sant’Ambrogio Hospital, Milan, Italy;3. Department of Advanced Biomedical Sciences, University Federico II, Naples, Italy;4. Division of Clinical Pharmacology, Department of Pharmacology, Showa University, Tokyo, Japan;5. Department of Cardiology, Zurich University Hospital, Zurich, Switzerland;7. Department of Clinical and Molecular Medicine, Sapienza University, Rome, Italy;8. Department of Cardiology, Lausanne University Hospital, Lausanne, Switzerland;1. Department of Chemical and Biomolecular Engineering, University of Nebraska-Lincoln, Nebraska, USA;2. Biomedical Engineering Program, University of Nebraska-Lincoln, Nebraska, USA;3. Department of Biological Systems Engineering, University of Nebraska-Lincoln, Nebraska, USA;4. Department of Vascular Surgery, Beijing Anzhen Hospital of Capital Medical University, Beijing Institute of Heart Lung and Blood Vessel Diseases, Beijing, China;5. Department of Genetics, Cell Biology and Anatomy, University of Nebraska Medical Center, Nebraska, USA;6. VA Nebraska Western-Iowa Health Care System, VA Medical Center, Nebraska, USA;7. Department of Radiation Oncology, College of Medicine, University of Nebraska Medical Center, Omaha, NE, USA;8. Division of Oncology and Hematology, Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE, USA;9. Department of Psychology, University of Nebraska-Lincoln, Nebraska, USA;10. Mary and Dick Holland Regenerative Medicine Program, University of Nebraska Medical Center, Omaha, NE, USA;11. Fred & Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, NE, USA;1. Faculty of Medicine, University of Tsukuba, Tsukuba, Japan;2. International Integrative Institute for Sleep medicine (WPI-IIIS), University of Tsukuba, Tsukuba, Japan;3. JST PRESTO, Japan;4. Memory Research Unit, Okinawa Institute of Science and Technology Graduate University (OIST), Okinawa, Japan;5. Institute of Innovative Research (IIR), Tokyo Institute of Technology, Tokyo, Japan;1. Department of Cardiac Development and Remodeling, Max Planck Institute for Heart and Lung Research, 61231 Bad Nauheim, Germany;2. German Centre for Cardiovascular Research (DZHK), Partner site Rhein-Main, Frankfurt am Main, Germany |
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| Abstract: | - 1.1. Proteinuria was induced in piglets (0–45 days after birth) by administration of sow colostrum and porcine serum intravenously or orally.
- 2.2. Electroimmunoassay and Sephadex gel nitration was used to quantitate and follow the fate in the organism of total protein, albumin, α-foetoprotein and colostrum prealbumin and to determine the molecular weights of these specific proteins.
- 3.3. Light microscopy and electronmicroscopy were used to study changes in vesicular activity in the proximal tubular cells during naturally occurring and induced proteinuria.
- 4.4. The transient proteinuria developed by the newborn piglet after ingestion of colostrum seems to be an effect of changes in amount and quality of protein on the capillary side of the glomerular cells and in function of the proximal tubular cells of the kidney.
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