扶正化瘀胶囊对心肌梗死大鼠心肌纤维化的影响

目的：急性心肌梗死是危害人类健康的重大疾病之一,心肌梗死后心肌纤维化是造成心脏结构破坏、心功能下降、心律失常发生、心衰甚至猝死的微观病理机制。防治心肌纤维化是当前医学研究的重点和热点。本研究主要探讨扶正化瘀胶囊对心肌梗死大鼠心肌纤维化的干预作用。方法：大鼠随机分为假手术组、模型组、扶正化瘀胶囊组和卡托普利组,采用结扎冠状动脉前降支的方法建立心肌梗死模型,假手术组只穿线,不结扎。于造模成功后第10天开始给予相应药物治疗2个月。治疗结束后,检测左心室梗死范围和心肌胶原含量。结果：与假手术组比较,模型组、扶正化瘀胶囊组和卡托普利组的非梗死区面积显著减小（P〈0.01）。与模型组比较,扶正化瘀胶囊组和卡托普利组的梗死区面积和梗死百分比显著减小（P〈0.05,P〈0.01）。在心肌胶原表达上,与假手术组比较,模型组和扶正化瘀胶囊组胶原含量显著增加（P〈0.01）。与模型组比较,卡托普利组和扶正化瘀胶囊组胶原含量显著降低（P〈0.05,P〈0.01）。结论：扶正化瘀胶囊能够改善心肌缺血,缩小心肌梗死范围,抑制心肌胶原表达,除能用于肝纤维化的治疗外,还能用于防治心肌梗死后的心肌纤维化。

Effects of Fuzhenghuayu Capsule on Myocardial Fibrosis in Rats with Myocardial Infarction

Objective： Acute myocardial infarction is one of the major diseases endangering human health.Myocardial fibrosis is the microscopic pathological mechanisms that caused by the structure of the heart damage,heart dysfunction,arrhythmia,heart failure and even sudden death after myocardial infarction.Prevention of myocardial fibrosis is the focus of current medical research and hotspots.The purpose of this study is to investigate the effects of Fuzhenghuayu capsule on myocardial fibrosis in rats with myocardial infarction.Methods： Rats were randomly divided into Sham operation group,model group,Fuzhenghuayu capsule（FZHY） group and captopril group.MI model of rats was established by ligating left anterior descending coronary artery,and rats in Sham operation group were only punctured without ligating.Rats were treated with corresponding drugs for two months from 10 days after modeling.After treatment left ventricular infarct size and myocardial collagen area were measured.Results： Compared with sham operation group,the non-infarcted area decreased remarkably in the model group,FZHY group and captopril group（P0.01）.Compared with model group,the infarct area and the percentage of infarct size decreased significantly in FZHY group and captopril group（P0.05,P0.01）.When it comes to expressions of myocardial collagen,compared with sham operation group,the left ventricular myocardial collagen expression area increased significantly in model group and FZHY group.Compared with model group,the myocardial collagen expression area decreased significantly in FZHY group and captopril group（P0.05,P0.01）.Conclusion： Fuzhenghuayu capsule can improve myocardial ischemia,reduce the scope of myocardial infarction and inhibit the expression of myocardial collagen.In addition to the treatment of liver fibrosis,Fuzhenghuayu capsule also can be used for the treatment of myocardial fibrosis after myocardial infarction.