Human serum does contain a high molecular weight hepatocyte growth factor: studies pre- and post-hepatic resection |
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| Authors: | C Selden R Johnstone H Darby S Gupta H J Hodgson |
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| Affiliation: | 1. Wang-Cai Biochemistry Lab, Division of Natural and Applied Sciences, Duke Kunshan University, Kunshan, Jiangsu, China;2. Global Health Research Center, Duke Kunshan University, Kunshan, Jiangsu, China;1. Silence Therapeutics GmbH, Robert-Rössle-Straße 10, 13125, Berlin, Germany;2. Silence Therapeutics PLC, 72 Hammersmith Road, London, W14 8TH, London, UK;1. Amgen Research, Pharmacokinetics and Drug Metabolism, 1120 Veterans Blvd., South San Francisco, CA 94080, USA;2. Amgen Research, Hybrid Modality Engineering, One Amgen Center Drive, Thousand Oaks, CA 91320, USA;3. Amgen Research, Cardiometabolic Disorders, One Amgen Center Drive, Thousand Oaks, CA 91320, USA |
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| Abstract: | ![]()
Levels of a high molecular weight hepatotrophin were measured in human serum taken from patients before and 24 hours after undergoing major hepatic resection. In in-vitro rat hepatocyte cultures a 'hepatotrophin' enriched fraction of human serum induced the incorporation of tritiated thymidine into DNA in both pre and post-operative patients. Levels after hepatic resection were 2-3 fold higher than those achieved at the same protein concentration before operation in the same patient. The hepatotrophic factor had an apparent molecular weight of approximately 150,000 daltons, and was an anionic protein. |
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