Role of inositol trisphosphate as a second messenger in signal transduction processes: An essay |
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| Authors: | N N Osborne A B Tobin H Ghazi |
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| Institution: | (1) Nuffield Laboratory of Ophthalmology, University of Oxford, Walton Street, OX2 6AW Oxford, U.K. |
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| Abstract: | This essay attempts to summarize some of the best evidence for the role of inositol trisphosphate as a second messenger in signal transduction processes. The following aspects are addressed in the essay: (a) The synthesis of inositol trisphosphate and other inositol lipids, (b) Receptor-phosphatidylinositol bisphosphate phospholipase C coupling and the N-ras protooncogene, (c) Inositol trisphosphate and intracellular calcium, (d) Cell growth and oncogenes, (e) Receptors linked to the phosphatidylinositol cycle, (f) Phototransduction and (g) Interactions between inositol trisphosphate and other second messengers.Abbreviations Cyclic AMP
Adenosine 3 ,5-cyclic monophosphate
- Cyclic GMP
Guanosine 3,5-cyclic monophosphate
- DG
sn, 1,2-Diacylglycerol
- EGF
Epidermal growth factor
- GDP
Guanosine diphosphate
- GTP
Guanosine triphosphate
- IP
Inositol 1-monophosphate
- IP2
Inositol 1,4-diphosphate
- IP3
Inositol 1,4,5-trisphosphate
- PA
Phosphatidic acid
- PDGF
Platelet-derived growth factor
- PI
Phosphatidylinositol
- PIP
Phosphatidylinositol 4-monophosphate
- PIP2
Phosphatidylinositol 4,5-bisphosphate
- PIP3
Phosphatidylinositol 3,4,5-trisphosphate
- PLC
Phospholipase C |
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| Keywords: | Inositol trisphosphate inositol lipids second messenger |
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