Four new diterpenoid alkaloids from Delphinium elatum |
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| Institution: | 1. Department of Vascular Surgery, Shandong Provincial Hospital affiliated to Shandong University, No. 324, Road Jing Wu Wei Qi, Jinan 250021, Shandong, China;2. Department of Vascular Surgery, Shandong Provincial Hospital affiliated to Shandong University, No. 324, Road Jing Wu Wei Qi, Jinan 250021, Shandong, China;3. Department of Neurology, First People''s Hospital affiliated to Shanghai Jiaotong University, No. 100, Road Hai Ning, Shanghai 200080, China;4. Department of Stomatology, Second People''s Hospital of Linyi City, No. 17, Road Jiang Kang, Yishui 276400, Shandong, China |
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| Abstract: | Diterpenoid alkaloids exhibit remarkable chemical properties and biological activities. Such compounds are frequently found in plants of the genera Aconitum, Delphinium, and Garrya. Several diterpenoid alkaloid components from Delphinium elatum cv. Pacific Giant and their derivatives exhibited cytotoxic activity against lung, prostate, nasopharyngeal, and vincristine-resistant nasopharyngeal cancer cell lines. Phytochemical investigations on the seeds of D. elatum cv. Pacific Giant led to the isolation of four new C19-diterpenoid alkaloids, melpheline (1), 19-oxoisodelpheline (2), N-deethyl-19-oxoisodelpheline (3), and N-deethyl-19-oxodelpheline (4). The isolated alkaloids were elucidated by extensive spectroscopic methods including NMR (1D and 2D), IR, and MS (HRMS). |
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| Keywords: | Melpheline 19-oxoisodelpheline |
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