Two new hydroxylated ent-kauranoic acids from Pteris semipinnata |
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| Institution: | 1. School of Chinese Materia medica, Guangzhou University of Chinese Medicine, Guangzhou 510006, China;2. School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou 510006, China;1. College of Bioengineering, Beijing Polytechnic, Beijing 100029, China;2. College of Pharmacy, Dalian Medical University, Dalian 116044, China;3. The Second Affiliated Hospital of Dalian Medical University, Dalian 116044, China;1. Department of Molecular Pharmacology, Kitasato University School of Pharmaceutical Sciences, 5-9-1 Shirokane, Minato-ku, Tokyo 108-8641, Japan;2. Department of Organic Synthesis, Kitasato University School of Pharmaceutical Sciences, 5-9-1 Shirokane, Minato-ku, Tokyo 108-8641, Japan;1. Laboratory for Conservation and Utilization of Bio-Resource, and Key Laboratory for Microbial Resources of the Ministry of Education, Yunnan University, Kunming 650091, China;2. Faculty of Medicine, Kunming University of Science and Technology, Kunming 650500, China;3. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, China;1. School of Pharmaceutical Sciences, Shandong University, 44 West Wenhua Road, Jinan, Shandong 250012, China;2. Shandong Analysis and Test Center, Jinan, Shandong 250014, China;3. Shandong Reyoung Pharmaceutical Co., Ltd., Yiyuan, Shandong 256100, China;4. Jiangsu Shengshi Kangde Biotech Corporation, Lianyungang, Jiangsu 222006, China;1. Gifu Pharmaceutical University, 1-25-4 Daigaku-nishi, Gifu, 501-1196, Japan;2. Osaka University of Pharmaceutical Sciences, 4-20-1 Nasahara, Takatsuki, Osaka, 569-1094, Japan;3. Ono Pharmaceutical Co., Ltd., 1-1, Sakurai 3, Shimamoto, Mishima, Osaka, 618-8585, Japan |
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| Abstract: | Two new hydroxylated ent-kauranoic acids, pterisolic acid G (1) and pterisolic acid H (3), together with five known ent-kaurane-type diterpenoids (2 and 4–7) were isolated from the whole plant of Pteris semipinnata L. The structures of compounds 1–3 were elucidated on the basis of HR-MS, 1D and 2D NMR analysis, and the absolute configuration of compounds 1 and 2 were determined by the results of single crystal X-ray diffraction experiment. Compounds 1–4 and 6–7 were evaluated in vitro cytotoxicity against the A549, CT26.WT, and Hep G2 cells, and compounds 4 and 6 possessed varying degrees of activity. |
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| Keywords: | Pterisolic acid G Pterisolic acid H Diterpenoids Cytotoxicity |
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