Anticomplement cycloartane triterpene glycosides from Beesia calthaefolia (Maxim.) |
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| Institution: | 1. College of Bioengineering, Beijing Polytechnic, Beijing 100029, China;2. College of Pharmacy, Dalian Medical University, Dalian 116044, China;3. The Second Affiliated Hospital of Dalian Medical University, Dalian 116044, China;1. Department of Chemistry, Faculty of Science, Universiti Teknologi Malaysia (UTM), 81310 Skudai, Johor, Malaysia;2. School of Chemistry and Environment Studies, Faculty of Applied Sciences, Universiti Teknologi MARA (UiTM) Sarawak, Jalan Meranek, 94300 Kota Samarahan, Sarawak, Malaysia;3. Department of Bioscience and Health Sciences, Faculty of Biosciences and Medical Engineering, Universiti Teknologi Malaysia (UTM), 81310 Skudai, Johor, Malaysia;4. Department of Pharmacy & Graduate Institute of Pharmaceutical Technology, Tajen University, Pingtung 907, Taiwan;5. Medicinal Chemistry and Natural Products Research Group, School of Pharmacy and Biomolecular Sciences, Faculty of Science, Liverpool John Moores University, James Parsons Building, Byrom Street, Liverpool L3 3AF, United Kingdom;1. UoN Chair of Oman’s Medicinal Plants and Marine Natural Products, University of Nizwa, P.O. Box 33, Postal Code 616, Birkat Al Mauz, Nizwa, Oman;2. Department of Chemistry, Federal Urdu University of Arts, Science and Technolgy, Karachi, Pakistan;3. Martin-Luther Universität Halle-Wittenberg, Organische Chemie, Kurt-Mothes-Str. 2, D-06120 Halle, Germany;4. DARIS Centre for Scientific Research and Technology Development, University of Nizwa, P.O. Box 33, Postal Code 616, Birkat Al Mauz, Nizwa, Oman;5. Department of Chemistry and Polymer Science, University of Stellenbosch, P/Bag X1, Matieland, 7602, South Africa;1. Key Laboratory of TCM Quality Control Technology of Shandong Province, Shandong Analysis and Test Center, 19 Keyuan Street, Jinan, Shandong 250014, PR China;2. Reyoung Pharmaceutical Co., Ltd., No. 44Cultural West Road, Jinan 250012, PR China;1. Department of Natural Products and Alternative Medicine, Faculty of Pharmacy, King Abdulaziz University, Jeddah 21589, Saudi Arabia;2. Department of Pharmacognosy, Faculty of Pharmacy, Al-Azhar University, Assiut Branch 71524, Assiut, Egypt;1. Chulabhorn Research Institute, Kamphaeng Phet 6, Talat Bang Khen, Lak Si, Bangkok 10210, Thailand;2. Faculty of Pharmaceutical Sciences, Khon Kaen University, Khon Kaen 40002, Thailand |
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| Abstract: | Investigation of the n-BuOH extract of the whole plant of Beesia calthaefolia led to the isolation of three new cycloartane triterpenoids (1–3) and two known compounds (4, 5). Their structures were elucidated by 1D and 2D NMR, HRESIMS and optical rotation spectral data. All of the isolates were investigated for their inhibitory effects on the classical pathway of the complement system. Among them, compound 3 showed stronger inhibitory activity (IC50 148.0 μM) than the positive control (rosmarinic acid, IC50 181.8 μM), while other compounds (1, 2, 4 and 5) showed moderate activity. The chemical compound studied in this article was rosmarinic acid (PubChem CID: 5281792). |
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| Keywords: | Cycloartane triterpene Anticomplement activity |
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