Phenolic compounds from the roots of Ochna schweinfurthiana and their antioxidant and antiplasmodial activities |
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| Affiliation: | 1. Department of Organic Chemistry, Faculty of Science, University of Yaoundé 1, P.O. Box 812, Yaoundé, Cameroon;2. Centre de Recherche en Plantes Médicinales et Médecine Traditionnelle (CRPMT), I.M.P.M., B.P. 6163, Yaoundé, Cameroon;3. Department of Chemistry, Higher Teacher Training College, University of Yaoundé 1, P. O. Box 47, Yaoundé, Cameroon;4. Laboratory of Microbiology, Faculty of science, University of Yaoundé 1, P.O. Box 812 Yaoundé, Cameroon;5. Laboratoire de Pharmacognosie, Centre Inter facultaire de Recherche sur le Médicament (CIRM), Département de Pharmacie, Université de Liège, B36, B-4000 Liège, Belgium;1. School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China;2. Development and Utilization Key Laboratory of Northeast Plant Materials, Key Laboratory of Northeast Authentic Materials Research and Development in Liaoning Province, School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, China;1. Laboratory of Animal Physiology, Department of Animal Biology and Physiology, Faculty of Science, University of Yaounde I, P.O. Box 812, Yaounde, Cameroon;2. Department of Pharmacognosy, University of Vienna, Althanstrasse 14, 1090 Vienna, Austria;3. Department of Pharmaceutical Chemistry, University of Vienna, Althanstrasse 14, 1090 Vienna, Austria;4. Institute of Organic Chemistry, University of Vienna, Währingerstraße 38, A-1090 Vienna, Austria;5. Department of Biotechnology, University of Natural Resources and Life Sciences Vienna, Muthgasse 18, A-1190 Vienna, Austria;1. Department of Food, Life, and Environmental Science, Faculty of Agriculture, Yamagata University, Tsuruoka, Yamagata 997-8555, Japan;2. Department of Chemistry, Faculty of Mathematics and Natural Sciences, University of Gadjah Mada, Yogyakarta 55281, Indonesia;3. Graduate School of Agriculture, Iwate University, Morioka, Iwate 020-8550, Japan;4. The United Graduate School of Agricultural Sciences, Iwate University, Morioka, Iwate 020-8550, Japan;1. Key Laboratory of Chemistry of Northwestern Plant Resources of the CAS and Key Laboratory for Natural Medicine of Gansu Province, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences (CAS), Lanzhou 730000, PR China;2. University of Chinese Academy of Sciences, Beijing 100039, PR China |
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| Abstract: | 
An investigation of compounds extracted from Ochna schweinfurthiana roots with ethyl acetate led to the isolation of three new compounds 4⿴-methoxylophirone A (1), 4,4⿲,4⿴⿿trimethoxylophirone A (2) and (4E;7Z)-3,8-dicarboxy-1-(O-β-d-glucopyranosyl-(1 ⿿ 6)-O-β-d-glucopyranosyl-2,9-dihydroxyhexeicosa-4,7-diene (3). Six known compounds were also identified, including Calodenone (4), Calodenine B (5), Lophirone A (6), Gerontoisoflavone A(7), 16α,17-dihydroxy-ent-kauran-19-oic acid (8) and 3β-O-d-glucopyranosyl-β-sitosterol (9). This report describes the first time that compounds 4-8 have been isolated from this plant, while 8 has never been identified in the genus Ochna. Some of the isolated compounds were evaluated for their antiplasmodial activity against the chloroquine-sensitive Plasmodium falciparum strain 3D7 and antioxidant activity using DPPH radical scavenging and Ferric reducing-antioxidant power (FRAP) assays. Compound 5 exhibited prominent radical scavenging and FRAP activities, while 7 had weak activity. Compound 1 showed good in vitro anti-plasmodial activity. The structures of the isolated compounds were elucidated by spectroscopic methods and comparisons with prior data in the literature. |
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| Keywords: | Ochnaceae Isobiflavonoid Structural elucidation Antioxidant and antiplasmodial activities |
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