Madangones A and B: Two new neolignans from the stem bark of Beilschmiedia madang and their bioactivities |
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| Institution: | 1. Department of Chemistry, Faculty of Science, Universiti Teknologi Malaysia (UTM), 81310 Skudai, Johor, Malaysia;2. School of Chemistry and Environment Studies, Faculty of Applied Sciences, Universiti Teknologi MARA (UiTM) Sarawak, Jalan Meranek, 94300 Kota Samarahan, Sarawak, Malaysia;3. Department of Bioscience and Health Sciences, Faculty of Biosciences and Medical Engineering, Universiti Teknologi Malaysia (UTM), 81310 Skudai, Johor, Malaysia;4. Medicinal Chemistry and Natural Products Research Group, School of Pharmacy and Biomolecular Sciences, Faculty of Science, Liverpool John Moores University, James Parsons Building, Byrom Street, Liverpool L3 3AF, United Kingdom;1. Department of Chemistry, Faculty of Mathematics & Natural Sciences, Universitas Indonesia, Kampus UI Depok, Jawa Barat 16424, Indonesia;2. Research Center for Chemistry, Indonesian Institute of Sciences, Kawasan PUSPIPTEK, Serpong, Tangerang Selatan, Banten 15314, Indonesia;1. School of Bioscience and Bioengineering, South China University of Technology, Guangzhou 510006, People’s Republic of China;2. Department of Pharmacy, General Hospital of Guangzhou Military Command, Guangzhou 510010, People’s Republic of China;3. Centre Laboratory, Guangdong Pharmaceutical University, Guangzhou 510006, People’s Republic of China;1. Department of Pharmacy, University of Naples Federico II, 80131, Italy;2. Department of Environmental Biological and Pharmaceutical Sciences and Technologies, Università degli Studi della Campania Luigi Vanvitelli, 81100 Caserta, Italy;3. Department of Experimental Medicine, Section of Microbiology and Clinical Microbiology, Università degli Studi della Campania Luigi Vanvitelli, Naples, 80138, Italy;4. Department of Mental and Physical Health and Preventive Medicine, Section of Human Anatomy, Università degli Studi della Campania Luigi Vanvitelli, Naples, 80138, Italy;1. Key Laboratory of Mountain Ecological Restoration and Bioresource Utilization, Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu 610041, PR China;2. College of Life Science, Sichuan University, Chengdu 610064, PR China;3. Shanghai University of Traditional Chinese Medicine, Shanghai 201203, PR China |
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| Abstract: | Two new neolignans, madangones A (1) and B (2), together with (+)-kunstlerone (3), vanillin, vanillic acid, betulin, β-sitosterol and β-sitostenone, were isolated from the stem bark of Beilschmiedia madang (Lauraceae). The structures of the compounds were determined by spectroscopic means. The compounds were tested for antioxidant, acetylcholinesterase inhibitory and anti-inflammatory activities. Compound (3) displayed the strongest DPPH radical-scavenging activity with an IC50 value of 68.7 μM. Compound (2) exhibited the highest level of activity on the COX-2 model and acetylcholinesterase inhibition assay, with IC50 values of 27.4 and 70.3 μM, respectively. |
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| Keywords: | Neolignan Antioxidant Acetylcholinesterase Anti-inflammatory |
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