Three new alkaloids from the twigs of Cassia siamea and their bioactivities |
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| Institution: | 1. Institute for Biological Research “Sini?a Stankovi?”, University of Belgrade, National Institute of Republic of Serbia, Bulevar despota Stefana 142, Belgrade 11060, Serbia;2. Laboratory of Biochemistry and Biotechnology, Department of Natural Sciences, Maxim Tank Belarusian State Pedagogical University, Sovetskaya 18, Minsk 200030, Belarus |
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| Abstract: | Three new tricyclic alkaloid, siamalkaloids A–C (1–3), together with three known alkaloids (3–6) were isolated from the twigs of Cassia siamea. Their structures were determined by means of HRESIMS and extensive 1D and 2D NMR spectroscopic studies. Compounds 1–6 were tested for their anti-tobacco mosaic virus (anti-TMV) activity, and compound 3 exhibited high anti-TMV activity with inhibition rate of 34.5%. This rate is higher than that of positive control. In addition, the cytotoxicity of compounds 1–6 were also tested, and compounds 2–6 showed weak activity with IC50 values ranging from 2.8 to 9.4 μM for some tested human tumor cell lines. |
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| Keywords: | Tricyclic alkaloid Anti-tobacco mosaic virus activity Cytotoxicity |
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