Cytotoxic acridone and indoloquinazoline alkaloids from Zanthoxylum poggei |
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| Institution: | 1. Department of Chemistry, University of Douala, Faculty of Science, 24157 Douala, Cameroon;2. School of Pharmacy and Biomolecular Sciences, Liverpool John Moores University, James Parsons Building, Byrom Street, Liverpool L3 3AF, UK;3. Department of Chemistry, University of Buea, Faculty of Sciene, 63 Buea, Cameroon;4. School of Pharmacy, Faculty of Science and Engineering, University of Wolverhampton, Wulfuna Street, Wolverhampton WV1 1LY, UK;1. State Key Laboratory of Analytical Chemistry for Life Science and Collaborative Innovation Center of Chemistry for Life Sciences, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210023, China;1. School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China;2. Development and Utilization Key Laboratory of Northeast Plant Materials, Key Laboratory of Northeast Authentic Materials Research and Development in Liaoning Province, School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, China;1. Key Laboratory of Chemistry of Northwestern Plant Resources of CAS and Key Laboratory for Natural Medicine of Gansu Province, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou 730000, PR China;2. Key Laboratory of Tibetan Medicine Research, Northwest Institute of Plateau Biology, Chinese Academy of Sciences, Xining 810008, PR China;3. University of Chinese Academy of Sciences, 100049, Beijing, PR China;1. Hebei TCM Formula Granule Engineering & Technology Research Center, Hebei University of Chinese Medicine, Shijiazhuang 050091, China;2. Hebei Province Center for Disease Prevention and Control, Shijiazhuang 050021, China;1. School of Biological and Food Engineering, Suzhou University, Bianhe Middle Road 49, Yongqiao, Suzhou, 234000, Anhui Province, China;2. Faculty of Applied and Medical Science, AL-Razi University, Al-Rebatt St., Sana’a ye700, Yemen;3. State Key Laboratory of Food Science and Technology, Jiangnan University, Lihu Avenue 1800, Wuxi, 214122, Jiangsu Province, China;4. Central Laboratories Administration, King Faisal University, Al-Ahsa, 31982, Saudi Arabia |
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| Abstract: | Two new alkaloids, poggeicridone (1) and 2-methoxy-7,8- dehydroruteacarpine (6), together with nine known compounds, were isolated from the dichloromethane (DCM) extract of the bark of Zanthoxylum poggei (Engl.) P. G. Waterman. The structures of all compounds were determined by comprehensive spectroscopic analyses (1D and 2D NMR and EI- and ESI⿿MS). Compounds 5-9 exhibited strong suppressive effects on the phagocytosis response upon activation with serum opsonized zymosan in the in vitro oxidative burst studies using whole blood. The IC50 values were in the range of 12.0⿿25.9 μM. These compounds displayed a moderate level of cytotoxic activity against the human Caucasian prostate adenocarcinoma cell line PC-3, with IC50 values of 15.8 and 22.1 μM (the IC50 value of the positive control standard doxorubicin was IC50 0.9 μM). All isolated compounds were also tested against plant pathogenic bacteria, fungi and oomycetes using the paper disk agar diffusion assay, resulting in no significant activities (MICs > 1 mg/mL). |
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| Keywords: | Rutaceae Acridone Indoloquinazoline alkaloids Oxidative burst inhibition Antimicrobial Cytotoxic activities |
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