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Respiratory mucosal delivery of next-generation COVID-19 vaccine provides robust protection against both ancestral and variant strains of SARS-CoV-2
Affiliation:1. McMaster Immunology Research Centre, M.G. DeGroote Institute for Infectious Disease Research, Department of Medicine, McMaster University, Hamilton, ON L8S 4K1, Canada;2. McMaster Immunology Research Centre, M. G. DeGroote Institute for Infectious Disease Research, Department of Biochemistry & Biomedical Sciences, McMaster University, Hamilton, ON L8S 4K1, Canada;3. Department of Pediatric Otolaryngology, Shenzhen Hospital, Southern Medical University, Shenzhen, China;4. Department of Pathology and Molecular Medicine, M.G. DeGroote Institute for Infectious Disease Research, McMaster University, Hamilton, ON L8S 4K1, Canada
Abstract:
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  • Keywords:SARS-CoV-2  COVID-19  variants of concern  next-generation vaccines  intramuscular immunization  respiratory mucosal immunization  multi-valent vaccine  adenoviral vector  human adenoviral vector  chimpanzee adenoviral vector  respiratory mucosal immunity  humoral immunity  T cell immunity  trained innate immunity  animal models
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