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Genomic architecture of autism from comprehensive whole-genome sequence annotation
Institution:1. The Centre for Applied Genomics, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada;2. Genetics and Genome Biology Program, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada;3. CGEn, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada;4. Verily Life Sciences, South San Francisco, CA 94080, USA;5. Ted Rogers Centre for Heart Research, The Hospital for Sick Children, Toronto, ON M5G 1X8, Canada;6. Department of Human Genetics, Sidra Medicine, Doha, Qatar;7. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar;8. Autism Research Unit, The Hospital for Sick Children, Toronto, ON M5G 1X8, Canada;9. Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A8, Canada;10. Department of Genetic Counselling, The Hospital for Sick Children, Toronto, ON M5G 1X8, Canada;11. Genome Diagnostics, Department of Paediatric Medicine, The Hospital for Sick Children, Toronto, ON M5G 1X8, Canada;12. Department of Laboratory Medicine and Pathobiology, The Hospital for Sick Children, Toronto, ON M5G 1X8, Canada;13. Neurosciences and Mental Health, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada;14. DNAstack, Toronto, ON M5H 1T1, Canada;15. Autism Speaks, Princeton, NJ 08540, USA;16. Department of Psychology, Queen''s University, Kingston, ON K7L 3N6, Canada;17. Department of Psychiatry, Queen''s University, Kingston, ON K7L 7X3, Canada;18. Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, Los Angeles, CA 90024, USA;19. Department of Family and Community Medicine, University of Toronto, Toronto, ON M5G 1V7, Canada;20. Dalla Lana School of Public Health, University of Toronto, Toronto, ON M5T 3M7, Canada;21. Department of Human Genetics, McGill University, Montreal, QC H3A 0C7, Canada;22. Department of Statistical Sciences, University of Toronto, Toronto, ON M5S 3G3, Canada;23. Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON M5S 1A8, Canada;24. Division of Clinical and Metabolic Genetics, The Hospital for Sick Children, Toronto, ON M5G 1X8, Canada;25. Department of Pediatrics, University of Toronto, Toronto, ON M5G 1X8, Canada;26. Department of Medical Genetics, University of British Columbia, Vancouver, BC V6H 3N1, Canada;27. BC Children''s Hospital Research Institute, Vancouver, BC V5Z 4H4, Canada;28. Holland Bloorview Kids Rehabilitation Hospital, Toronto, ON M4G 1R8, Canada;29. Montreal Neurological Institute, McGill University, Montreal, QC H3A 2B4, Canada;30. Department of Psychology, The Hospital for Sick Children, Toronto, ON M5G 1X8, Canada;31. Department of Psychiatry, School of Medicine, Trinity College Dublin, Dublin 2, Ireland;32. Department of Psychiatry, The Hospital for Sick Children, Toronto, ON M5G 1X8, Canada;33. Child, Youth and Family Services, The Centre for Addiction and Mental Health, Toronto, ON M6J 1H4, Canada;34. Department of Psychiatry, University of Toronto, Toronto, ON M5T 1R8, Canada;35. MIND Institute, University of California, Davis, Sacramento, CA 95817, USA;36. Department of Psychiatry and Behavioral Sciences, University of California, Davis, Sacramento, CA 95817, USA;37. Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, ON L8N 3K7, Canada;38. Department of Psychology, University of Miami, Miami, FL 33124, USA;39. Department of Psychiatry and Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA 92093, USA;40. Queen''s Genomics Lab at Ongwanada, Queen''s University, Kingston, ON K7M 8A6, Canada;41. Department of Pediatrics, Dalhousie University, Halifax, NS B3H 4R2, Canada;42. IWK Health Centre, Halifax, NS B3K 6R8, Canada;43. Centre for Addiction and Mental Health, Toronto, ON M6J 1H4, Canada;44. Department of Pediatrics, University of Alberta, Edmonton, AB T6G 1C9, Canada;45. Institute of Biomedical Engineering, University of Toronto, Toronto, ON M5S 3G9, Canada;46. Department of Psychology, John Carroll University, Cleveland, OH 44118, USA;47. Department of Genetic Medicine, Weill Cornell Medical College in Qatar, Doha, Qatar;48. Department of Pediatrics, Children''s Hospital Los Angeles, Los Angeles, CA 90027, USA;49. Keck School of Medicine of USC, University of Southern California, Los Angeles, CA 90033, USA;50. McLaughlin Centre, Toronto, ON M5G 0A4, Canada
Abstract:
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  • Keywords:autism spectrum disorder  neurodevelopmental disorders  whole-genome sequencing  copy-number variation  structural variation  rare variants  polygenic risk scores  phenotype measures
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