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Deep mutational scanning identifies SARS-CoV-2 Nucleocapsid escape mutations of currently available rapid antigen tests
Affiliation:1. Department of Biochemistry, Emory University School of Medicine, Emory University, Atlanta, GA 30322, USA;2. The Atlanta Center for Microsystems-Engineered Point-of-Care Technologies, Atlanta, GA 30322, USA;3. Department of Pediatrics, Emory University School of Medicine, Atlanta, GA 30322, USA;4. Center for Childhood Infections and Vaccines of Children’s Healthcare of Atlanta, Emory University, Atlanta, GA 30322, USA;5. Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA;6. Department of Medicine, Division of Infectious Diseases, Emory University School of Medicine, Atlanta, GA 30322, USA;7. Wallace H. Coulter Department of Biomedical Engineering, Emory University, Georgia Institute of Technology, Atlanta, GA 30332, USA;8. Aflac Cancer and Blood Disorders Center of Children’s Healthcare of Atlanta, Atlanta, GA 30322, USA;9. Emory Vaccine Center, Emory University School of Medicine, Atlanta, GA 30322, USA;10. Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA 30322, USA
Abstract:
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  • Keywords:SARS-CoV-2 Nucleocapsid protein  deep mutational scanning  mammalian surface-display  antibodies  rapid diagnostic tests  variants  epitope mapping
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