Genetic Variations in COMT and DRD2 Modulate Attentional Bias for Affective Facial Expressions |
| |
| Authors: | Pingyuan Gong Guomin Shen She Li Guoping Zhang Hongchao Fang Lin Lei Peizhe Zhang Fuchang Zhang |
| |
| Institution: | 1. Center for Brain and Cognitive Sciences and Department of Psychology, Peking University, Beijing, China.; 2. Laboratory of Medical Molecular Biology, Henan University of Science and Technology, Luoyang, China.; 3. China Academy of Corporate Governance/Business School, Nankai University, Tianjin, China.; 4. Institute of Population and Health, College of Life Science, Northwest University, Xi''an, China.; Xi''an Jiaotong Univesity School of Medicine, China, |
| |
| Abstract: | Studies have revealed that catechol-O-methyltransferase (COMT) and dopaminegic receptor2 (DRD2) modulate human attention bias for palatable food or tobacco. However, the existing evidence about the modulations of COMT and DRD2 on attentional bias for facial expressions was still limited. In the study, 650 college students were genotyped with regard to COMT Val158Met and DRD2 TaqI A polymorphisms, and the attentional bias for facial expressions was assessed using the spatial cueing task. The results indicated that COMT Val158Met underpinned the individual difference in attentional bias for negative emotional expressions (P = 0.03) and the Met carriers showed more engagement bias for negative expressions than the Val/Val homozygote. On the contrary, DRD2 TaqIA underpinned the individual difference in attentional bias for positive expressions (P = 0.003) and individuals with TT genotype showed much more engagement bias for positive expressions than the individuals with CC genotype. Moreover, the two genes exerted significant interactions on the engagements for negative and positive expressions (P = 0.046, P = 0.005). These findings suggest that the individual differences in the attentional bias for emotional expressions are partially underpinned by the genetic polymorphisms in COMT and DRD2. |
| |
| Keywords: | |
|
|
