Cell death pathology: perspective for human diseases |
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| Authors: | Agostini Massimiliano Tucci Paola Melino Gerry |
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| Affiliation: | aMedical Research Council, Toxicology Unit, Leicester, UK;bBiochemistry IDI-IRCCS Laboratory and Dept. Experimental Medicine, University of Rome, Tor Vergata, 00133 Rome, Italy |
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| Abstract: | Apoptosis, a genetically regulated form of cell death with distinct biochemical and morphological features, plays a relevant physiological and pathological role in the organism, being pivotal in the maintenance of tissue development and homeostasis in the adult as well as in the regulation of immune responses. Deregulation of this process causes several human disorders including cancer, autoimmune and neurodegenerative diseases. Thus, modulation of the apoptotic process and of cell death in general, is a potential therapeutic approach for the treatment of several human pathologies. |
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| Keywords: | Abbreviations: AIDS, acquired immune deficiency syndrome TIAF1, TGFβ-induced anti-apoptotic factor 1 TGFβ, transforming growth factor beta AD, Alzheimer disease APP, amyloid precursor protein PD, Parkinson&rsquo s disease NSC, neural stem cells AICD, activation induced cell death HIV, human immunodeficiency virus |
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