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Cytomegaloviral hypophysitis in a simian immunodeficiency virus‐infected rhesus macaque (Macacca mulatta) |
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| Authors: | Melissa R Berg Michael A Owston Marie‐Claire Gauduin Basel T Assaf Anne D Lewis Edward J Dick Jr |
| Institution: | 1. Southwest National Primate Research Center at the Texas Biomedical Research Institute, San Antonio, TX, USA;2. Oregon National Primate Research Center, Beaverton, OR, USA;3. Department of Virology and Immunology, Texas Biomedical Research Institute, San Antonio, TX, USA |
| Abstract: | Rhesus macaques experimentally infected with Simian Immunodeficiency Virus (SIV) experience immunosuppression and often opportunistic infection. Among the most common opportunistic infections are rhesus cytomegalovirus (RhCMV), a ubiquitous betaherpesvirus that undergoes continuous low‐level replication in immunocompetent monkeys. Upon SIV‐mediated immunodeficiency, RhCMV reactivates and results in lesions in numerous organ systems including the nervous and reproductive systems. We report the first case of cytomegaloviral hypophysitis in a SIV‐immunocompromised rhesus macaque. |
| Keywords: | cytomegalovirus inclusions intra‐cytoplasmic intranuclear model non‐human primate pituitary viral |